Papilloma and malignancy.
The role of HPV in the etiopathogenesis of inverted papilloma. Source: ORL. In its etiopathogenesis, human papilloma viruses, Epstein-Barr virus or papilloma and malignancy factors are incriminated, and there is no unequivocal evidence for any of them.
The most common genetic change in head and neck cancers is the p53 suppressor gene mutation, with a protective effect against the apoptotic response of damaged DNA cells.
Viral oncoproteins E6 and E7 are involved in the suppression of p53, with the disruption of cell cycle control. Suppression of p21 universally present in inverted papilloma lesions associated with p53 has been identified in all HPV-positive inverted papillomas with severe dysplasia.
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